6533b827fe1ef96bd1285b19
RESEARCH PRODUCT
Hemophilia A and Hemophilia B
Craig M. KesslerMariasanta Napolitanosubject
hemophilia A hemophilia B treatment clinical featuresmedicine.medical_specialtyIntramuscular hemorrhageHemophiliasTransmission (medicine)business.industrymedicineHemarthrosisIntensive care medicinemedicine.diseasebusinessdescription
Abstract While observed for centuries, the diseases that we call hemophilia have been clarified and elucidated in the past 50 to 60 years. We now know the genetics and transmission of the various types of hemophilia and are greatly facilitated by their laboratory features. Various hemorrhagic manifestations of the various hemophilias include hemarthrosis, intramuscular hemorrhage, retroperitoneal bleeding, retropharyngeal bleeding, and central nervous system hemorrhage. In the past, trauma and surgery were associated with serious or fatal bleeding. Now, multiple agents are available to treat or prophylax against hemorrhage. Specific diagnoses require specific therapeutics. Fatal hemorrhagic events have largely disappeared. Newer therapeutic agents have been developed with biochemical attributes allowing for prolonged duration of infused hemostatic agents. The development of gene therapy is a distinct possibility.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-01 |