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RESEARCH PRODUCT

MOESM8 of The distributions of protein coding genes within chromatin domains in relation to human disease

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Additional file 8: Figure S7. Mean ratios of the number of enhancers per gene within the TADs versus the number of genes within the TAD associated with disease (0 ≤ k ≤ n), where n is the total number of genes within the TAD. The value of n, which determines the TAD category, is represented for TADs with n = 1, 2, 3, and 4 genes (red, blue, green and purple lines, respectively). TADs with fewer TSSs have higher ratios of enhancers to TSSs. Moreover, for each TAD category, the higher the number of genes associated with disease, the higher the average number of enhancers per gene.