6533b827fe1ef96bd1285b6e
RESEARCH PRODUCT
Oral conditions and salivary analysis in HIV-uninfected subjects using preexposure prophylaxis.
N. MacedoG. BaggioI. HennJ. SantosT. BatistaS. IgnácioP. SouzaL. Azevedo-alanissubject
Malemouth neoplasmsDental Plaque IndexHIV InfectionsSalivary Gland DiseasesXerostomiasurvival analysisOtorhinolaryngologysquamous cell carcinoma of head and neckHumansSurgerylip neoplasmsCalciumFemaleSalivaGeneral Dentistryoropharyngeal neoplasmsUNESCO:CIENCIAS MÉDICASdescription
New prevention strategies have been advocated to control the progression of HIV/AIDS, such as preexposure prophylaxis (PrEP). The aim of this study is to evaluate the potential changes in the oral and salivary conditions of HIV-uninfected subjects using PrEP. Subjects were evaluated before beginning the medication (T0), at the first follow-up (T1), and at the second follow-up (T2). Xerostomia, presence of untreated cavitated caries, oral hygiene habits, taste, gingival and plaque index, stimulated salivary flow rate (SSFR), and salivary concentrations of calcium, glucose, urea, and total proteins were evaluated. Data obtained were analyzed using statistical tests (p0.05), except for the salivary calcium concentration, that increased at T2 compared to T1 (p=0.02). There was significant difference between taste and xerostomia at T1 (p=0.017), and the need to drink to swallow at T2 (p=0.015). There was significant correlation between the reported amount of saliva and taste (p=0.039, r=-0.378) at T1. The prolonged use of PrEP seems to be associated with reports of dry mouth and worsening of taste, possibly associated with increased salivary calcium concentration.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-10-07 | Medicina oral, patologia oral y cirugia bucal |