6533b827fe1ef96bd1285bf6
RESEARCH PRODUCT
Efficacy and tolerability of a fixed dose combination of cortex phospholipid liposomes and cyanocobalamin for intramuscular use in peripheral neuropathies
Lorenza LauricellaSofia TomaselloGiulia Letizia MauroDalila ScaturroMichele Vecchiosubject
Viitamin B 12Fixed-dose combinationAnalgesicPharmacologyInjections IntramuscularInjections03 medical and health sciences0302 clinical medicinePharmacotherapyPeripheral nervous system diseasemedicineHumansCyanocobalaminphospholipidPhospholipidsCerebral CortexIntramuscularAnalgesicsClinical Trials as TopicNeck painLiposomebiologybusiness.industrySettore MED/34 - Medicina Fisica E RiabilitativaBack painPeripheral Nervous System DiseasesGeneral MedicineBack pain; Liposomes; Neuralgia; Peripheral nervous system diseases; Phospholipids; Vitamin B 12; Analgesics; Cerebral Cortex; Clinical Trials as Topic; Drug Combinations; Humans; Injections Intramuscular; Liposomes; Neuroprotective Agents; Peripheral Nervous System Diseases; Phospholipids; Vitamin B 12Drug CombinationsVitamin B 12Neuroprotective AgentsTolerability030220 oncology & carcinogenesisLiposomesbiology.proteinNeuralgia030211 gastroenterology & hepatologyIiposomemedicine.symptombusinessNeurotrophindescription
Peripheral neuropathies are frequently encourtered in clinical practice and are assiociated with a major impairment in quality of life . Howewvwr, their management reamans poor, and current therapies are often burdened with major side effects and can present poor efficacy on pain and functionality. Therefore, it has been suggested that the combination of two or more different drugs may improve analgesis efficacy and reduce side effects. Tricortin 1000 is formulated with 12 mg of Brain cortex phospholipid liposomes + 1000 microgrammi of Cyanocobalamin injectable (PL+ CNCb1) for intramuscolar use and is indicated in the tratment of poly-algo-neuropathic syndromes. This combination exerts a marked neurotrophic action by promoting the syntesis of endogenous phospholipids; moreover the peculiar formulation optimized the delivery of CNCb1 wich has analgesis and neurotrophic action. This paper discusses the pharmacotherapy of peripheral neuropathies, including low back pain, neck pain, post herpetic neuropathy (PHN) and focuses on the fixed dose combination PL+CNCb1 ckinical efficacy in association with other treatment or in monotherapy.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-01 | Minerva Medica |