6533b827fe1ef96bd1285cd6
RESEARCH PRODUCT
Hepatitis B and C virus variants in long-term immunosuppressed renal transplant patients in Latvia.
Juris JansonsRafails RozentalsEriks SmagrisInese FolkmaneIrina SominskayaPaul PumpensViktorija EmelyanovaMarija MihailovaUga Dumpissubject
AdultMaleHepatitis B virusGenes ViralGenotypeHepatitis B virus DNA polymerasemedicine.medical_treatmentSequence HomologyHepacivirusVirusHepatitis B virus PRE betaVirologymedicineImmune ToleranceHumansPoint MutationDialysisPhylogenyAgedbusiness.industryIncidence (epidemiology)Hepatitis CHepatitis BMiddle Agedmedicine.diseaseHepatitis BVirologyHepatitis CKidney TransplantationLatviaTransplantationInfectious DiseasesAmino Acid SubstitutionFemalebusinessSequence Analysisdescription
The incidence of genome variants of hepatitis B and hepatitis C viruses among 38 long-term (2–15 years) immunosuppressed patients after renal transplantation and 10 patients undergoing dialysis was investigated. Twelve patients had only HBV infection, 9 had only HCV infection and 14 were co-infected. Regions corresponding to the HBV X/EnII/BCP, preC/C, preS/S and to the HCV core were sequenced for molecular characterization of the HBV and HCV genomes. Fifty-seven percent of HBV DNA isolates belonged to genotype D and 42% to genotype A, whereas 77% of HCV RNA isolates belonged to genotype 1b and only 17% to genotype 3a. One sample (6%) was of genotype 2c. Detailed analysis of the above-mentioned HBV genome regions revealed the presence of nucleotide point mutations, which, in some cases, resulted in amino acid substitutions. The clinical significance of such mutations is discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-02-02 | Intervirology |