Defective apoptosis and tumorigenesis: role of p53 mutation and Fas/FasL system dysregulation

6533b827fe1ef96bd1285d7e

RESEARCH PRODUCT

Defective apoptosis and tumorigenesis: role of p53 mutation and Fas/FasL system dysregulation

Fabio Bucchieri Francesco Cappello A. Palma Marianna Bellafiore

subject

Fas Ligand Protein Histology Free Radicals Cell Biophysics Apoptosis Biology medicine.disease_cause Fas ligand Neoplasms medicine Animals Humans fas Receptor Transcription factor lcsh:QH301-705.5 Membrane Glycoproteins fungi Cancer food and beverages Genetic Therapy Cell Biology Genes p53 medicine.disease Genes bcl-2 medicine.anatomical_structure lcsh:Biology (General)Apoptosis Tumor progression Immunology Carcinogenesis Cytokine receptor

description

The transcription factor p53 and the cytokine receptor FasL are two of the most famous regulators of cell life, and their alterations can cause a large number of pathologies, including cancer. In this review, we focused on how they can determine defective apoptosis, one of the causes of tumorigenesis and tumor progression. The importance of this knowledge lies in the new perspectives that gene therapy can offer to cure cancer.

year	journal	country	edition	language
2010-01-23	European Journal of Histochemistry

10.4081/1680 https://www.ejh.it/index.php/ejh/article/view/1680

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