6533b827fe1ef96bd1285e09
RESEARCH PRODUCT
Bacterial etiology of community-acquired pneumonia in immunocompetent hospitalized patients and appropriateness of empirical treatment recommendations: an international point-prevalence study
Manuela CarugatiS. AlibertiG. SotgiuF. BlasiA. GoriR. MenendezM. EnchevaM. GallegoP. LeuschnerS. Ruiz-buitragoS. BattagliaR. FantiniS. Pascual-guardiaJ. Marin-corralM. I. RestrepoPatricia Karina ArujSilvia AttorriEnrique BarimboimJuan Pablo CaeiroMaría I GarzónVictor Hugo CambursanoAdrian CeccatoJulio ChertcoffFlorencia LascarFernando Di TulioAriel Cordon DíazLautaro De VediaMaria Cristina GanahaSandra LambertGustavo LopardoCarlos M LunaAlessio Gerardo MalbertiNora MorcilloSilvina TartaraClaudia PensottiBetiana PereyraPablo Gustavo ScapellatoJuan Pablo StagnaroSonali ShahFelix LötschFlorian ThalhammerJean Louis VincentKurt AnseeuwCamille A FrancoisEva Van BraeckelMarcel Zannou DjimonJules BashiDodo RogerSimone Aranha NouérPeter ChipevMilena EnchevaDarina MitevaDiana PetkovaBalkissou Adamou DodoMbatchou NgahaneBertrand HugoNing ShenJin-fu XuCarlos Andres Bustamante RicoRicardo BuitragoFernando Jose Pereira PaterninaKayembe Ntumba Jean-marieVesna Vladic CarevicMarko JakopovicMateja JankovicZinka MatkovicIvan MitrecicMarie-laure Bouchy JacobssonAnette Bro ChristensenUff E Christian HeitmannbødtgerChristian Niels MeyerAndreas Vestergaard JensenGertrud Baunbæk-knudsenPelle Trier PetersenStine AndersenIbrahim El-said Abd El-wahhabNesreen Elsayed MorsyHanaa ShafiekEman SobhFabrice BertrandChristian Brun-buissonEtienne De MontmollinMuriel FartoukhJonathan MessikaPierre TattevinMichael DreherMartin KolditzMatthias MeisingerMathias W PletzStefan HagelJan RuppTom SchabergMarc SpielmannsBeatrice Siaw-larteyKaterina DimakouDimosthenis PapapetrouEvdoxia TsigouDimitrios AmpazisMohit BhatiaRaja DharGeorge D’souzaRajiv GargParvaiz A KoulP A MaheshB S JayarajKiran Vishnu NarayanHirennappa B UdnurShashi Bhaskara KrishnamurthyKeihan GolshaniVera M KeatingsIgnacio Martin-loechesYasmin MaorJacob StrahilevitzSalvatore BattagliaMaria CarrabbaPiero CerianaMarco ConfalonieriAntonella D’arminio MonforteBruno Del PratoMarino De RosaRiccardo FantiniGiuseppe FiorentinoMaria Antonia GamminoFrancesco MenzellaGiuseppe MilaniStefano NavaGerardo PalmieroRoberta PetrinoBarbra GabrielliPaolo RossiClaudio SorinoGundi SteinhilberAlessandro ZanforlinKiyoyasu KurahashiZeina Aoun BachaDaniel Barajas UgaldeOmar Ceballos ZuñigaJosé F VillegasMilic MedenicaE M W Van De GardeDeebya Raj MihsraPoojan ShresthaElliott RidgeonBabatunde Ishola AwokolaOgonna N O NwankwoAdefuye Bolanle OlufunlolaSegaolu OlumideKingsley N UkwajaMuhammad IrfanLukasz MinarowskiSkoczyński SzymonFelipe FroesPedro LeuschnerMariana MeirelesCláudia FerrãoPedro LeuschnerJoão NevesSofia B RavaraCova Da BeiraVictoria BrocovschiiChesov IonDoina RusuCristina TomaDaniela ChiritaAlexei BirkunAnna KaluzheninaAbdullah AlmotairiZakeya AbdulbaqiAli BukharyJameela EdathoduAmal FathyAbdullah Mushira Abdulaziz EnaniNazik Eltayeb MohamedJawed Ulhadi MemonNada BogdanovićBranislava MilenkovicDragica PesutLuis BorderìasNoel Manuel Bordon GarciaHugo Cabello AlarcónCatia CillonizAntoni TorresVicens Diaz-britoXavier CasasAlicia Encabo GonzálezMaria Luisa Fernández-almiraMiguel GallegoInmaculada Gaspar-garcíaJuan González Del CastilloPatricia Javaloyes VictoriaElena Laserna MartínezRosa Malo De MolinaPedro J MarcosRosario MenéndezAna PandosandovaCristina Prat AymerichAlicia Lacoma Del La TorreIgnasi García-olivéJordi RelloSilvia MoyanoFrancisco SanzOriol SibilaAna Rodrigo-troyanoJordi Solé-violánAne UrangaJob Fm Van BovenEster Vendrell TorraJordi Almirall PujolCharles FeldmanHo Kee YumArnauld Attannon FiogbeFerdaous YanguiSemra BilacerogluLevent DalarUfuk YilmazArtemii BogomolovNaheed ElahiDevesh J DhasmanaRhiannon IonsJulie SkeemerGerrit WoltmannCarole HancockAdam T HillBanu RudranSilvia Ruiz-buitragoMarion CampbellPaul WhitakerKaren S AllenVeronica BritoJessica DietzClaire E DysartSusan M KellieRicardo A Franco-sadudGarnet MeierMina GagaThomas L HollandStephen P BerginFayez KheirMark LandmeierManuel LoisGirish B NairHemali PatelKatherine ReyesWilliam Rodriguez-cintronShigeki SaitoNilam J SoniJulio NodaCecilia I HinojosaStephanie M LevineLuis F AngelAntonio AnzuetoK Scott WhitlowJohn HipskindKunal SukhijaRichard G. WunderinkRay D ShahKondwelani John Mateyosubject
Male0301 basic medicineMicrobiology (medical)medicine.medical_specialtyCommunity-acquired pneumonia030106 microbiologyAntimicrobial treatmentPrevalenceGuidelineSettore MED/10 - Malattie Dell'Apparato RespiratorioGuidelinesGlobal Healthmedicine.disease_causeImmunocompromised Host03 medical and health sciences0302 clinical medicineMedical microbiologyCommunity-acquired pneumoniaInternal medicineEpidemiologyStreptococcus pneumoniaePneumonia BacterialPrevalenceHumansMedicine030212 general & internal medicinePractice Patterns Physicians'AgedAged 80 and overbusiness.industryCorrectionGeneral MedicineGuidelineMiddle Agedmedicine.diseaseAnti-Bacterial AgentsCommunity-Acquired InfectionsHospitalizationPneumoniaInfectious DiseasesStreptococcus pneumoniaePractice Guidelines as TopicPseudomonas aeruginosaEtiologyOriginal ArticleFemaleGuideline Adherencebusinessdescription
An accurate knowledge of the epidemiology of community-acquired pneumonia (CAP) is key for selecting appropriate antimicrobial treatments. Very few etiological studies assessed the appropriateness of empiric guideline recommendations at a multinational level. This study aims at the following: (i) describing the bacterial etiologic distribution of CAP and (ii) assessing the appropriateness of the empirical treatment recommendations by clinical practice guidelines (CPGs) for CAP in light of the bacterial pathogens diagnosed as causative agents of CAP. Secondary analysis of the GLIMP, a point-prevalence international study which enrolled adults hospitalized with CAP in 2015. The analysis was limited to immunocompetent patients tested for bacterial CAP agents within 24 h of admission. The CAP CPGs evaluated included the following: the 2007 and 2019 American Thoracic Society/Infectious Diseases Society of America (ATS/IDSA), the European Respiratory Society (ERS), and selected country-specific CPGs. Among 2564 patients enrolled, 35.3% had an identifiable pathogen. Streptococcus pneumoniae (8.2%) was the most frequently identified pathogen, followed by Pseudomonas aeruginosa (4.1%) and Klebsiella pneumoniae (3.4%). CPGs appropriately recommend covering more than 90% of all the potential pathogens causing CAP, with the exception of patients enrolled from Germany, Pakistan, and Croatia. The 2019 ATS/IDSA CPGs appropriately recommend covering 93.6% of the cases compared with 90.3% of the ERS CPGs (p < 0.01). S. pneumoniae remains the most common pathogen in patients hospitalized with CAP. Multinational CPG recommendations for patients with CAP seem to appropriately cover the most common pathogens and should be strongly encouraged for the management of CAP patients. Electronic supplementary material The online version of this article (10.1007/s10096-020-03870-3) contains supplementary material, which is available to authorized users.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-01 |