Neiromediatora serotonīna ietekme uz augļu mušu (Drosophila melanogaster) kustību lateralitāti

6533b827fe1ef96bd1285fa6

RESEARCH PRODUCT

Neiromediatora serotonīna ietekme uz augļu mušu (Drosophila melanogaster) kustību lateralitāti

subject

y-tipa labirints serotonīns Drosophilia melanogaster Bioloģija kustību lateralitāte

description

Augļu mušu (Drosophila melanogaster) depresīvā uzvedības modeļa izpēte ar y-tipa labirinta metodi, var palīdzēt saprast depresīvās uzvedības pamatelementus. Augļu mušas ir labi pazīstams un plaši pielietojams modeļobjekts bioloģijas nozares pētījumos, ir zināms, ka serotonīna sintēzes cikls ir evolucionāri konservatīvs, līdzīgs visiem dzīvniekiem, tāpēc ir svarīgi apzināties kādus ķīmiskos līdzekļus vislabāk pielietot tālakos uzvedības pētījumos. Darba mērķis ir izpētīt vai selektīvie serotonīna inhibitori ietekmē augļu mušu Oregon R kustību lateritāti. Kopā pētījumā analizēti, selektīvā serototonīna atpakaļpiesaistes inhibitora escitaloprāma un, vielas ar antidepresīvām īpašībām, triptofāna ietekme uz D. melanogaster kustību lateralitāti. Augļu mušu kultūras sagatavošana un izpēte veikta Daugavpils Universitātes augļu mušu laboratorijā. Paraugu uzvedības īpatnības novērotas ar y-tipa labirinta metodi, izmantojot HD kameru ar sensoru, rezultāti apkopoti tabulā, pēc kuras sagatavots grafiks. Pētīto augļu mušu ietvaros, D. melanogaster laterālās kustības paredzamība samazinājās escitaloprāma ietekmē, bet triptofāna ietekmē netika novērotas būtiskas atšķirības, salīdzinot ar kontroles grupu

year	journal	country	edition	language
2022-01-01

https://dspace.lu.lv/dspace/handle/7/59215

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