6533b827fe1ef96bd128643c

RESEARCH PRODUCT

Pretrichodermamide C and N-methylpretrichodermamide B, two new cytotoxic epidithiodiketopiperazines from hyper saline lake derived Penicillium sp.

Peter ProkschWenhan LinRaha OrfaliWerner E.g. MüllerMohamed S. Abdel-azizGeorgios DaletosWeaam EbrahimWeaam EbrahimAmal H. Aly

subject

Murine lymphomaStereochemistrymedicine.medical_treatmentPlant ScienceNuclear magnetic resonance spectroscopyBiologyMass spectrometrybiology.organism_classificationBiochemistryMicrobiologyPenicilliummedicineCytotoxic T cellCytotoxicityAgronomy and Crop ScienceSalineBiotechnology

description

Abstract Two new epidithiodiketopiperazines, pretrichodermamide C (1) and N-methylpretrichodermamide B (2) were isolated from the fungus Penicillium sp., derived from the sediment of a hyper saline lake located at Wadi El-Natrun in Egypt. The structures of 1 and 2 were unambiguously determined on the basis of one- and two-dimensional NMR spectroscopy and by high-resolution mass spectrometry, as well as by comparison with the literature. Compound 2 showed pronounced cytotoxicity against the murine lymphoma L5178Y cell line with an IC50 value of 2 μM.

yearjournalcountryeditionlanguage
2015-03-01Phytochemistry Letters
https://doi.org/10.1016/j.phytol.2014.12.010