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RESEARCH PRODUCT
Fetal/Neonatal Thyrotoxicosis in a Newborn From a Hypothyroid Woman With Hashimoto Thyroiditis.
Tanja DianaKatrin Klebermass-schrehofGregor KasprianManuel SteinerChristof WordaGeorge J. KahalyAlois GesslFlorian W. Kiefersubject
Adultendocrine systemmedicine.medical_specialtyendocrine system diseasesEndocrinology Diabetes and MetabolismGraves' diseaseClinical Biochemistry030209 endocrinology & metabolismContext (language use)DiseaseHashimoto DiseaseBiochemistryThyroiditisInfant Newborn Diseases03 medical and health sciences0302 clinical medicineEndocrinologyHypothyroidismPregnancyInternal medicinemedicineHumansHashimoto DiseaseFetusPregnancybusiness.industryBiochemistry (medical)Infant NewbornTransplacentalmedicine.diseasePrognosisPregnancy ComplicationsFetal DiseasesEndocrinologyThyrotoxicosis030220 oncology & carcinogenesisFemalebusinesshormones hormone substitutes and hormone antagonistsImmunoglobulins Thyroid-Stimulatingdescription
Context: Fetal/neonatal thyrotoxicosis is a rare but potentially life-threatening condition. It is most commonly observed in poorly controlled Graves’ disease during pregnancy. Case Description: Here we describe the first reported case of thyrotoxicosis in a fetus/newborn from a woman with Hashimoto’s thyroiditis and levothyroxine-treated hypothyroidism. Transplacental passage of stimulating TSH-receptor antibodies, measured by a cell-based bioassay, was the underlying mechanism of fetal/neonatal thyrotoxicosis even though the mother had no history of hyperthyroidism. Conclusion: Diagnosis and management of fetal hyperthyroidism can be challenging. TSH receptor antibody testing should be considered in pregnant women with any history of autoimmune thyroid disease and symptoms of fetal hyperthyroidism.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-11-04 | The Journal of clinical endocrinology and metabolism |