6533b827fe1ef96bd12866e6

RESEARCH PRODUCT

Structural changes induced by daily music listening in the recovering brain after middle cerebral artery stroke: a voxel-based morphometry study

Teppo EsärkämöTeppo EsärkämöPablo EripollésPablo EripollésHenna EvepsäläinenTaina EauttiHeli M SilvennoinenEero EsalliSari ElaitinenAnita EforsblomSeppo EsoinilaAntoni Erodríguez-fornellsAntoni Erodríguez-fornells

subject

6162 Cognitive sciencespeechAudiologyBehavioral NeuroscienceEARLY-ONSET STIMULATIONSPATIAL NORMALIZATIONArcuate fasciculusmagnetic resonance imagingCerebrovascular diseaseOriginal ResearchSUPPORTED THERAPYmagneettikuvausstrokehumanitiesPsychiatry and Mental healthNeuropsychology and Physiological Psychologymedicine.anatomical_structureNeurologyNeuroplasticitatta6131PsychologyMalalties cerebrovascularsmedicine.medical_specialtyCOST FUNCTION MASKING515 PsychologyneuroplasticitymusiikkiAuditory cortexbehavioral disciplines and activitiesLateralization of brain functionlcsh:RC321-571rehabilitationMagnetic resonance imagingWORKING-MEMORYImatges per ressonància magnèticamedicinevoxel-based morphometrymusicneuroplastisuuslcsh:Neurosciences. Biological psychiatry. NeuropsychiatryBiological PsychiatryAnterior cingulate cortexWorking memoryENRICHED-ENVIRONMENTARCUATE FASCICULUSVoxel-based morphometryta3124Superior frontal gyrusenvironmental enrichmentkuntoutusNeuroplasticity3111 BiomedicineVerbal memorySENSORIMOTOR CORTEXNeuroscienceMusicNeuroscienceMúsicaAUDITORY-CORTEXNEUROTROPHIC FACTOR

description

[Abstract.] Music is a highly complex and versatile stimulus for the brain that engages many temporal, frontal, parietal, cerebellar, and subcortical areas involved in auditory, cognitive, emotional, and motor processing. Regular musical activities have been shown to effectively enhance the structure and function of many brain areas, making music a potential tool also in neuro- logical rehabilitation. In our previous randomized controlled study, we found that listening to music on a daily basis can improve cognitive recovery and improve mood after an acute mid- dle cerebral artery stroke. Extending this study, a voxel-based morphometry (VBM) analysis utilizing cost function masking was performed on the acute and 6-month post-stroke stage structural magnetic resonance imaging data of the patients ( n D 49) who either listened to their favorite music [music group (MG), n D 16] or verbal material [audio book group (ABG), n D 18] or did not receive any listening material [control group (CG), n D 15] during the 6- month recovery period. Although all groups showed significant gray matter volume (GMV) increases from the acute to the 6-month stage, there was a specific network of frontal areas [left and right superior frontal gyrus (SFG), right medial SFG] and limbic areas [left ven- tral/subgenual anterior cingulate cortex (SACC) and right ventral striatum (VS)] in patients with left hemisphere damage in which the GMV increases were larger in the MG than in the ABG and in the CG. Moreover, the GM reorganization in the frontal areas correlated with enhanced recovery of verbal memory, focused attention, and language skills, whereas the GM reorganization in the SACC correlated with reduced negative mood. This study adds on previous results, showing that music listening after stroke not only enhances behavioral recovery, but also induces fine-grained neuroanatomical changes in the recovering brain. peerReviewed

yearjournalcountryeditionlanguage
2014-04-17
10.3389/fnhum.2014.00245http://hdl.handle.net/10138/160030