Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study

6533b827fe1ef96bd128673b

RESEARCH PRODUCT

Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study

Nancy Babio Judith B Ramírez Sabio Estefanía Toledo Estefanía Toledo José Lapetra Miguel Ruiz-canela Miguel Ruiz-canela Jordi Salas-salvadó Pablo Hernández-alonso Pablo Hernández-alonso Miquel Fiol Emilio Ros Emilio Ros Lluis Serra-majem Lluis Serra-majem Xavier Pintó Laura Barrubés Olga Castañer Montserrat Fitó Ramon Estruch Ramon Estruch Dolores Corella Dolores Corella Manuel Macias-gonzalez Manuel Macias-gonzalez ÁNgel M. Alonso-gómez ÁNgel M. Alonso-gómez

subject

PREDIMED medicine.medical_specialty Estils de vida Colorectal cancer WCRF/AICR score Lifestyles lcsh:Medicine colorectal cancer Article 03 medical and health sciences 0302 clinical medicine Interquartile range Càncer colorectal Internal medicine medicine lifestyle patterns 030212 general & internal medicine AICR score business.industry Incidence (epidemiology)Hazard ratio lcsh:R General Medicine medicine.disease Predimed Confidence interval WCRF low-risk lifestyle index 030220 oncology & carcinogenesis Cohort business Body mass index

description

Limited longitudinal studies have been conducted to evaluate colorectal cancer (CRC) incidence based on the updated 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations or other global lifestyle indices, and none in aged populations at high cardiovascular risk. We aimed to assess the association between CRC incidence and adherence to two emerging lifestyles indices (2018 WCRF/AICR score and another low-risk lifestyle (LRL) score comprising smoking status, alcohol consumption, physical activity, diet, and body mass index) in the Spanish PREvencion con DIeta MEDiterranea (PREDIMED) cohort. We studied 7216 elderly men and women at high cardiovascular risk. The 2018 WCRF/AICR and LRL scores were calculated. Multivariable Cox proportional regression models were fitted to estimate the HRs (hazard ratios) and 95% confidence intervals (CIs) for incident CRC events. During a median interquartile range (IQR) follow-up of 6.0 (4.4&ndash

year	journal	country	edition	language
2020-04-01	Journal of Clinical Medicine

10.3390/jcm9041215 https://www.mdpi.com/2077-0383/9/4/1215