6533b827fe1ef96bd12867c6

RESEARCH PRODUCT

Amphiphilic Dendrimers Control Protein Binding and Corona Formation on Liposome Nanocarriers

Klaus MüllenMarcel DillenburgerJessica WagnerTanja WeilJennifer OberländerJennifer OberländerDavid Y. W. NgVolker MailänderVolker MailänderKatharina LandfesterJohanna SimonJohanna Simon

subject

DendrimersPolymersSurface PropertiesPlasma protein bindingCatalysisCorona (optical phenomenon)AdsorptionDendrimerAmphiphileMaterials ChemistryHumansLiposomeChemistryMetals and AlloysBlood ProteinsGeneral ChemistrySurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsLiposomesCeramics and CompositesBiophysicsNanoparticlesProtein CoronaAdsorptionNanocarriersPalladiumProtein BindingProtein adsorption

description

Amphiphilic polyphenylene dendrimers (PPDs) with distinct lipophilic and positively or negatively charged surface groups were adsorbed onto liposomes and their impact on protein adsorption in blood plasma was studied. The PPD corona reduced binding of specific opsonins and increased the adsorption of proteins controlling cellular uptake based on their surface patches.

yearjournalcountryeditionlanguage
2020-06-19
10.1039/d0cc02486dhttps://hdl.handle.net/21.11116/0000-0006-D844-A21.11116/0000-0006-95F4-E