6533b827fe1ef96bd12867ee
RESEARCH PRODUCT
Ion conduction in the KcsA potassium channel analyzed with a minimal kinetic model.
Julio PellicerSalvador Mafesubject
Materials scienceIon TransportPotassium ChannelsCell MembraneKcsA potassium channelElectric ConductivityThermodynamicsIon-associationThermal conductionModels BiologicalPotassium channelDissociation (chemistry)IonMembrane PotentialsKineticsReaction rate constantBacterial ProteinsModels ChemicalPotassiumPhysical chemistryComputer SimulationIon Channel GatingIon channeldescription
We use a model by Nelson to study the current-voltage and conductance-concentration curves of bacterial potassium channel KcsA without assuming rapid ion translocation. Ion association to the channel filter is rate controlling at low concentrations, but dissociation and transport in the filter can limit conduction at high concentration for ions other than ${\mathrm{K}}^{+}$. The absolute values of the effective rate constants are tentative but the relative changes in these constants needed to qualitatively explain the experiments should be of significance.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-07-02 | Physical review. E, Statistical, nonlinear, and soft matter physics |