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RESEARCH PRODUCT

355 Night shift work and prostate cancer risk in a population-based case-control study in Spain

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Objectives Recent epidemiologic and animal data indicate that night work may increase the risk of cancer and specifically breast cancer. There is limited evidence on other hormone related cancers. We evaluated prostate cancer risk and night shift work in a population based case-control study in Spain, the MCC-Spain. Methods Incident prostate cancer cases (n = 1117) and randomly selected population controls (n = 1165) were enrolled in 7 regions of Spain. Lifetime occupational history including details on shift work, and information on lifestyle factors were assessed by face-to-face interviews. We estimated the risk of different shift profiles using unconditional logistic regression models adjusting for a wide range of potential confounders. Results Among the 2282 subjects, 12% reported having ever worked in permanent night shift and 17% in rotating night shift for ≥1 year. Having ever worked in night work (including permanent and rotating) was associated with a small and non-significant increased risk for prostate cancer (Odds Ratio (OR) 1.15, 95%CI 0.94–1.39) compared to day workers, after adjusting for age, centre, educational level and family history. This small increase was due to an increase in the ORs for rotating night shift workers (OR = 1.26, 95%CI 0.99–1.63). ORs were slightly increased for workers with more than 30 years permanent night work (OR = 1.22) and those in rotating shift (OR = 1.34). Results will be presented for different shift profiles and lifetime cumulative exposure. Conclusions In this large population based study we did not find an overall clear increase in prostate cancer risk associated with permanent or rotating night work. The analysis is ongoing and, at the conference, results will be presented for more detailed exposure classifications of night shift. (Additional authors: G. Castano, CREAL, Barcelona, M. Rivas-Fresno, Hospital Cabuenes, Asturias)