Xenopus Oocyte’s Conductance for Bioactive Compounds Screening and Characterization

6533b827fe1ef96bd1286efc

RESEARCH PRODUCT

Xenopus Oocyte’s Conductance for Bioactive Compounds Screening and Characterization

Noureddine Bouzouaya Balkiss Bouhaouala-zahar Balkiss Bouhaouala-zahar Hager Tabka Yassine Tlili Rym Benkhalifa Amani Cheikh Andrea Santulli

subject

Antioxidant Sodium medicine.medical_treatment Xenopus chemistry.chemical_element Endogeny +Sodium Channels Catalysis Article Amiloride Inorganic Chemistry lcsh:Chemistry Xenopus laevis chemistry.chemical_compound Xenopus oocyte INa Astaxanthin Drug Discovery medicine Animals Physical and Theoretical Chemistry Molecular Biology IC50 lcsh:QH301-705.5 Spectroscopy Xenopus oocyte INa+Biological Products bioactive compounds biology Sodium channel Organic Chemistry <i>Xenopus</i> oocyte INa<sup>+</sup>marine natural products General Medicine biology.organism_classification Electrophysiological Phenomena Computer Science Applications Shrimp astaxanthin chemistry Biochemistry lcsh:Biology (General)lcsh:QD1-999 Oocytes

description

Background: Astaxanthin (ATX) is a lipophilic compound found in many marine organisms. Studies have shown that ATX has many strong biological properties, including antioxidant, antiviral, anticancer, cardiovascular, anti-inflammatory, neuro-protective and anti-diabetic activities. However, no research has elucidated the effect of ATX on ionic channels. ATX can be extracted from shrimp by-products. Our work aims to characterize ATX cell targets to lend value to marine by-products. Methods: We used the Xenopus oocytes cell model to characterize the pharmacological target of ATX among endogenous Xenopus oocytes&rsquo

year	journal	country	edition	language
2019-04-01	International Journal of Molecular Sciences

10.3390/ijms20092083 https://www.mdpi.com/1422-0067/20/9/2083

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