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RESEARCH PRODUCT
Use of Ambient Ionization High-Resolution Mass Spectrometry for the Kinetic Analysis of Organic Surface Reactions
Jorge EscorihuelaMaarten M. J. SmuldersRickdeb SenHan ZuilhofHan Zuilhofsubject
Kinetic analysisKineticsAnalytical chemistry010402 general chemistryKinetic energyMass spectrometry01 natural sciencesReaccions químiquesElectrochemistryLife ScienceGeneral Materials ScienceSpectroscopyAmbient ionizationVLAG010405 organic chemistryChemistryOrganic ChemistrySurfaces and InterfacesCondensed Matter PhysicsDART ion sourceOrganische ChemieCycloaddition0104 chemical sciencesOrganic reactionChemical physicsQuímica orgànicadescription
In contrast to homogeneous systems, studying the kinetics of organic reactions on solid surfaces remains a difficult task due to the limited availability of appropriate analysis techniques that are general, high-throughput, and capable of offering quantitative, structural surface information. Here, we demonstrate how direct analysis in real time mass spectrometry (DART-MS) complies with above considerations and can be used for determining interfacial kinetic parameters. The presented approach is based on the use of a MS tag that - in principle - allows application to other reactions. To show the potential of DART-MS, we selected the widely applied strain-promoted alkyne-azide cycloaddition (SPAAC) as a model reaction to elucidate the effects of the nanoenvironment on the interfacial reaction rate.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 | Langmuir |