6533b827fe1ef96bd1287207

RESEARCH PRODUCT

Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil

Fernanda Patrícia GulloMaria José Soares Mendes-gianniniDulce Helena Siqueira SilvaCosimo PizzaCristiano Soleo FunariAna Marisa Fusco-almeidaSonia PiacenteRenato Lajarim CarneiroAssunta Napolitano

subject

AntifungalAntifungal AgentsIridoidStereochemistrymedicine.drug_classPharmaceutical ScienceMicrobial Sensitivity TestsCandida parapsilosisAntifungalAnalytical Chemistrychemistry.chemical_compoundVerbascosideCandida kruseiBotanyVerbenaceaeDrug DiscoverymedicineCandida albicansCandida spp.Cryptococcus neoformansPharmacologyLippiaTraditional medicinebiologyPlant ExtractsChemistryVerbenaceaeOrganic ChemistryFungiGeneral MedicineDereplicationbiology.organism_classificationComplementary and alternative medicineCryptococcus neoformansMolecular MedicineLippiaLippia sppBrazilFood Science

description

Made available in DSpace on 2013-09-27T14:52:47Z (GMT). No. of bitstreams: 1 WOS000310396700165.pdf: 536437 bytes, checksum: d267984ddfcb57d1406b069856adcc25 (MD5) Previous issue date: 2012-12-01 Made available in DSpace on 2013-09-30T19:10:31Z (GMT). No. of bitstreams: 1 WOS000310396700165.pdf: 536437 bytes, checksum: d267984ddfcb57d1406b069856adcc25 (MD5) Previous issue date: 2012-12-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T14:20:39Z No. of bitstreams: 1 WOS000310396700165.pdf: 536437 bytes, checksum: d267984ddfcb57d1406b069856adcc25 (MD5) Made available in DSpace on 2014-05-20T14:20:39Z (GMT). No. of bitstreams: 1 WOS000310396700165.pdf: 536437 bytes, checksum: d267984ddfcb57d1406b069856adcc25 (MD5) Previous issue date: 2012-12-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) The Lippia genus is used in ethnobotany as food, beverages, seasoning and antiseptic remedies, among others. The chemical compositions of fifteen extracts of six Lippia species were investigated comparatively by HPLC-PDA. To avoid data replication of previous works on this genus, Lippia lupulina Cham. root ethanol extract was selected for isolation procedures based on Principal Component Analyses (PCA) of such data. Seven compounds previously unreported in this genus were isolated from this extract (a triterpene, two furanonaphtoquinones, a furanochromone, an isoflavone, a stilbene and an iridoid). The activities of extracts, fractions and pure compounds towards Candida albicans, Candida krusei, Candida parapsilosis and Cryptococcus neoformans were investigated. Two fractions from the extract of Lippia salviaefolia leaves showed marked inhibition of fungal growth, in addition to verbascoside and asebogenin, which showed MICs lower than 15.6 mu g/ml and may be promising leads for the development of new antifungal agents, especially against C. neoformans. (C) 2012 Elsevier Ltd. All rights reserved. São Paulo State Univ, Inst Chem, NuBBE, BR-14801970 Araraquara, SP, Brazil São Paulo State Univ, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil Universidade Federal de São Carlos (UFSCar), Dept Chem, BR-13565905 São Carlos, SP, Brazil Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Fisciano, SA, Italy São Paulo State Univ, Inst Chem, NuBBE, BR-14801970 Araraquara, SP, Brazil São Paulo State Univ, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil FAPESP: 04/07932-7

yearjournalcountryeditionlanguage
2012-12-01Planta Medica
https://doi.org/10.1055/s-0032-1321106