6533b827fe1ef96bd1287233

RESEARCH PRODUCT

Blood flow and metabolic microenvironment of brain tumors

P. Vaupel

subject

Cancer Researchmedicine.medical_specialtyNeurologyPartial PressureBrain tumorContext (language use)AstrocytomaPharmacologyOxygen ConsumptionRadiation sensitivitymedicineAnimalsHumansCytotoxicityAcidosismedicine.diagnostic_testBrain Neoplasmsbusiness.industryGliomaBlood flowmedicine.diseaseOxygenNeurologyOncologyRegional Blood FlowPositron emission tomographyCerebrovascular CirculationNeurology (clinical)medicine.symptombusiness

description

Summarizing thesein vivo data in the context of brain tumor therapy, the following aspects are of particular importance: Low and heterogeneous tumor blood flow may — in addition to the limiting effects of the blood-brain barrier — result in compromised delivery of drugs from blood to the tissue. Low tumor pO2 reduces sensitivity to standard radiation and ‘O2-dependent’ anticancer drugs. Treatment efficacy may be further altered by changes of tumor pH. Particularly acidosis can decrease radiation sensitivity and modulate the cytotoxicity of anticancer drugs. In the following presentations, these aspects will be discussed regardingin vivo data obtained with positron emission tomography.

yearjournalcountryeditionlanguage
1994-01-01Journal of Neuro-Oncology
https://doi.org/10.1007/bf01052931