High Expression of Cannabinoid Receptor 2 on Cytokine-Induced Killer Cells and Multiple Myeloma Cells

6533b827fe1ef96bd128727c

RESEARCH PRODUCT

High Expression of Cannabinoid Receptor 2 on Cytokine-Induced Killer Cells and Multiple Myeloma Cells

Ingo G.h. Schmidt-wolf Francesca Garofano

subject

Cytotoxicity Immunologic Adoptive cellular immunotherapy Endocannabinoid system cytokine-induced killer cells CD3 Multiple myeloma.Plasma cell Peripheral blood mononuclear cell Article Catalysis Receptor Cannabinoid CB2 lcsh:Chemistry Inorganic Chemistry Immune system Cell Line Tumor medicine Humans Cannabidiol Cytotoxic T cell Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Cells Cultured Spectroscopy Cytokine-induced killer cell biology Chemistry Organic Chemistry General Medicine Computer Science Applications multiple myeloma Haematopoiesis Cytokine-induced killer cell medicine.anatomical_structure lcsh:Biology (General)lcsh:QD1-999 Cancer research biology.protein Bone marrow

description

Multiple myeloma (MM) is characterized by aberrant bone marrow plasma cell (PC) proliferation and is one of the most common hematological malignancies. The potential effect of cannabinoids on the immune system and hematological malignancies has been poorly characterized. Cannabidiol (CBD) may be used to treat various diseases. CBD is known to exert immunomodulatory effects through the activation of cannabinoid receptor 2 (CB2), which is expressed in high levels in the hematopoietic system. Cytokine-induced killer (CIK) cells are a heterogeneous population of polyclonal T lymphocytes obtained via ex vivo sequential incubation of peripheral blood mononuclear cells (PBMCs) with interferon-&gamma

year	journal	country	edition	language
2020-05-01	International Journal of Molecular Sciences

https://doi.org/10.3390/ijms21113800

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