6533b828fe1ef96bd1287794

RESEARCH PRODUCT

The Role of Monoamines in the Development of Cold-Induced Edema

H. J. ReulenA. FenskeK. Sinterhauf

subject

medicine.medical_specialtyChemistryBrain edemaEndogenyBrain tissueMonoamine neurotransmitterEndocrinologyInternal medicineEdemamedicineFluid accumulationEdema formationmedicine.symptomEarly phase

description

Our results show that even the experimentally induced high concentrations of exogenous 5-HT in the brain tissue during the early phase of edema formation are not able to increase the amount of fluid accumulation in the normal and injured brain tissue. The changes of the endogenous 5-HT levels in the blood and the brain tissue result in similar hemispheric water and RISA differences between the injured and uninjured half of the brain. Moreover, 5-HT concentrations elevated by 100% failed to produce detectable edema in the normal brain tissue of the rat.

yearjournalcountryeditionlanguage
1976-01-01
https://doi.org/10.1007/978-3-642-66524-0_25