0000000000017142
AUTHOR
A. Fenske
Extracellular space and electrolyte distribution in cortex and white matter of dog brain in cold induced oedema
24 hours after a circumscribed cold injury of the cortex dog brains were perfused from the lateral ventricle and the frontal subarachnoidal space to the cisterna magna with an artificial CSF containing trace amounts of35S-labelled thiosulphate. Simultaneously the extracellular tracer was administered intravenously. Extracellular fluid volume was estimated and found to be increased from 10 to 15% in the oedematous cortex and from 10 to 27% in the oedematous white matter. The actual size of ECS in oedematous white matter, however, must be larger as indicated by the relative alterations of thiosulphate distribution, tissue water, sodium and chloride. Apparently a small part of the fluid accumu…
The Role of Monoamines in the Development of Cold-Induced Edema
Our results show that even the experimentally induced high concentrations of exogenous 5-HT in the brain tissue during the early phase of edema formation are not able to increase the amount of fluid accumulation in the normal and injured brain tissue. The changes of the endogenous 5-HT levels in the blood and the brain tissue result in similar hemispheric water and RISA differences between the injured and uninjured half of the brain. Moreover, 5-HT concentrations elevated by 100% failed to produce detectable edema in the normal brain tissue of the rat.
Cerebral Oxygen Supply in Brain Edema and During Ventriculo-Cisternal Perfusion
Numerous brain injuries and brain tumors lead to edema in brain tissue which can have consequences for the oxygen supply to the damaged tissue as well as to adjacent tissue areas. In studies made of the blood flow and oxygen supply in perifocal edematous tissue of brain tumors and lesions in patients undergoing various brain operations a direct relationship between the regional blood flow and the water content could be demonstrated (3). As the water content of the tissue increased, the blood flow through it diminished. In many cases, the reduction of the blood flow in the brain tissue induced an insufficient oxygen supply. In the tissue samples under investigation, the CrP and ATP concentra…
Intracranial pressure and pressure volume relation in patients with subarachnoid haemorrhage (SAH)
The development of the intracranial pressure after a subarachnoid haemorrhage was evaluated in 21 patients. A statistically significant relation between the intracranial pressure and the neurological findings was found, whereas vasospasms did not influence the intracranial pressure. In patients in a clinically critical condition, rhythmic pressure waves of a frequency of 1/minute were repeatedly observed.
Giant aneurysm of the vertebral artery causing compression of the lower medulla oblongata
Es wird ein Fall geschildert, bei welchem durch ein Riesenaneurysma am Abgang der Arteria cerebellaris posterior inferior von der linken A. vertebralis zu einer Kompression der Oblongata mit rasch progredienter Tetraparese gefuhrt hatte. An der analogen Stelle an der rechten Vertebralis wurde ein zweites kleineres Aneurysma gefunden.
The Role of Tissue Pressure and Bulk Flow in the Formation and Resolution of Cold-Induced Edema
The mechanisms responsible for the dynamics of cold-induced edema, its spread and resolution, were examined. The findings indicate that bulk flow and not diffusion should be considered as the main mechanism for the edema spreading through the extracellular spaces of the white matter.