6533b828fe1ef96bd1287917

RESEARCH PRODUCT

Chronic non-invasive glucocorticoid administration decreases polysialylated neural cell adhesion molecule expression in the adult rat dentate gyrus

Juan NacherBruce S. McewenMaría ÁNgeles Gómez-climent

subject

Doublecortin Domain ProteinsMalemedicine.medical_specialtyCentral nervous systemAdministration OralCell CountNeural Cell Adhesion Molecule L1BiologyRats Sprague-Dawleychemistry.chemical_compoundCorticosteroneInternal medicinemedicineAnimalsPermissiveGlucocorticoidsNeuronsCell growthGeneral NeuroscienceDentate gyrusNeuropeptidesNeurogenesisImmunohistochemistryRatsKi-67 AntigenEndocrinologymedicine.anatomical_structureGene Expression Regulationnervous systemchemistryDentate GyrusSialic AcidsNeural cell adhesion moleculeMicrotubule-Associated ProteinsGlucocorticoidmedicine.drug

description

The expression of the polysialylated neural cell adhesion molecule (PSA-NCAM) is increased in the hippocampus after chronic restraint stress (CRS) and may play a permissive role in structural changes that include dendrite reorganization in dentate gyrus (DG) and CA3 pyramidal neurons and suppression of neurogenesis in DG. We report that chronic oral corticosterone (CORT) administration decreases the number of PSA-NCAM immunoreactive granule neurons in the adult rat dentate gyrus, and the available evidence suggests that this is an indirect effect of CORT, possibly involving excitatory amino acids, that may not be directly related to neurogenesis. Because CORT treatment reduces but does not eliminate PSA-NCAM expression, the present results do not exclude a permissive role for PSA-NCAM in CORT or CRS-induced structural plasticity in hippocampus.

yearjournalcountryeditionlanguage
2004-06-11Neuroscience Letters
https://doi.org/10.1016/j.neulet.2004.07.062