Corpus callosum function in verbal dichotic listening: inferences from a longitudinal follow-up of Relapsing-Remitting Multiple Sclerosis patients.

6533b828fe1ef96bd1287986

RESEARCH PRODUCT

Corpus callosum function in verbal dichotic listening: inferences from a longitudinal follow-up of Relapsing-Remitting Multiple Sclerosis patients.

Raúl Espert Estanislao Arana Alicia Salvador Marien Gadea Bonaventura Casanova Luis Martí-bonmatí

subject

Adult Male Linguistics and Language medicine.medical_specialty Cognitive Neuroscience Splenium Experimental and Cognitive Psychology Audiology Neuropsychological Tests Corpus callosum Severity of Illness Index Language and Linguistics Functional Laterality Developmental psychology Corpus Callosum Speech and Hearing Young Adult Multiple Sclerosis Relapsing-Remitting Stop consonant Vowel Prohibitins medicine Humans Active listening Age of Onset Analysis of Variance Dichotic listening Phonology Cognition Magnetic Resonance Imaging Acoustic Stimulation Auditory Perception Disease Progression Female Psychology Follow-Up Studies

description

This study conducted a follow-up of 13 early-onset slightly disabled Relapsing-Remitting Multiple Sclerosis (RRMS) patients within an year, evaluating both CC area measurements in a midsagittal Magnetic Resonance (MR) image, and Dichotic Listening (DL) testing with stop consonant vowel (C-V) syllables. Patients showed a significant progressive loss of posterior CC areas (isthmus and splenium) related to increasing EDSS scores and an enhancing right ear advantage (REA) over time. A significant correlation between posterior CC areas and DL scores emerged in both evaluations, being negative for the right and positive for the left ear. The pattern of correlations suggests that the CC can serve an inhibitory and also excitatory influence on the contralateral hemisphere when studying the phonological processing of language. Statement of significance to the neuroscience of language: The scope of the manuscript is language lateralization. The task used in the experiment is a verbal dichotic listening task, tapping the most basic phonological aspects of language. Finally, the available research is scarce when focusing on the interhemispheric excitation or inhibition of the corpus callosum in linguistic functioning.

year	journal	country	edition	language
2009-08-01	Brain and language

10.1016/j.bandl.2009.03.006 https://pubmed.ncbi.nlm.nih.gov/19419759