6533b828fe1ef96bd1287a08

RESEARCH PRODUCT

Systemic risk factors for peri-implant bone loss: a systematic review and meta-analysis

C. MicarelliLuigi CanulloDavid PeñarrochaPaulo Henrique Orlato RossettiWellington Cardoso BonachelaM. Clementini

subject

bone loss; risk factors; meta-analysis; systemic diseases; smoking; dental implantsSystemic diseasemedicine.medical_specialtyGenetic traitsAlveolar Bone LossMEDLINEDentistryPeri implant bonesmokingbone lossRisk FactorsInternal medicinemedicineSystemic riskHumansIMPLANTES DENTÁRIOSDental Restoration FailureDental Implantsbusiness.industryDental Implantation EndosseousEvidence-based medicinemedicine.diseasemeta-analysissystemic diseasesOtorhinolaryngologyMeta-analysisSurgeryImplantOral Surgerybusiness

description

The aim of this study was to determine the influence of patient-related systemic risk factors (systemic disease, genetic traits, chronic drug or alcohol consumption, and smoking status) on peri-implant bone loss at least 1 year after implant installation and prosthetic loading. An electronic search was performed of MEDLINE, EMBASE, and The Cochrane Central Register of Controlled Trials up to January 2012. One thousand seven hundred and sixty-three studies were identified. After applying a three-stage screening process, 17 articles were included in the qualitative analysis, but only 13 in the quantitative analysis, since smoking was a common exposure. The meta-analysis of these 13 studies (478 smokers and 1207 non-smokers) revealed a high level of heterogeneity and that smoking increases the annual rate of bone loss by 0.164 mm/year. Exposure to smoking had a harmful effect on peri-implant bone loss. However, the level of evidence for oral implant therapy in patients with systemic conditions is very low. Future studies should be improved in order to provide more robust data for clinical application.

yearjournalcountryeditionlanguage
2014-01-01
10.1016/j.ijom.2013.11.012