Clinicopathological Significance of Exosomal Proteins CD9, CD63 and DNA Mismatch Repair Proteins in Prostate Adenocarcinoma and Benign Hyperplasia

6533b828fe1ef96bd1287e33

RESEARCH PRODUCT

Clinicopathological Significance of Exosomal Proteins CD9, CD63 and DNA Mismatch Repair Proteins in Prostate Adenocarcinoma and Benign Hyperplasia

Kristofs Folkmanis

subject

Oncology Medicine Medicīna

description

Promocijas darbā vērtēta eksosomu biomarķieru un DNS neatbilstību reparācijas (MMR) proteīnu ekspresija un tās diagnostiskā nozīme pacientiem ar labdabīgu prostatas hiperplāziju (LPH) un prostatas karcinomu (PCa). Retrospektīvā pētījumā iekļauti 92 pacienti ar PCa un 20 pacienti ar LPH. Eksosomu un DNS MMR proteīnu ekspresija audos analizēta ar imūnhistoķīmijas metodi (IHC). Pētījumā konstatēta negatīva korelācija starp DNS MMR proteīnu zudumu un audzēja gradācijas grupām. Bezrecidīvu dzīvildze pacientiem ar DNS MMR deficītu bija ievērojami īsāka nekā pacientiem ar saglabātu DNS MMR ekspresiju. CD63 pārmērīga ekspresija, kā arī samazināta CD9 ekspresija raksturīga īsākai audzēja bezrecidīvu dzīvildzei. EKSOSOMU BIOMARĶIERI, DNS NEATBILSTĪBU REPARĀCIJAS PROTEĪNI, IMŪNHISTOĶĪMIJA, LABDABĪGA PROSTATAS HIPERPLĀZIJA, PROSTATAS KARCINOMA.

year	journal	country	edition	language
2021-01-01

https://dspace.lu.lv/dspace/handle/7/57125

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