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RESEARCH PRODUCT
Extractive-spectrophotometric determination of amphetamine in urine samples with sodium 1,2-naphthoquinone 4-sulphonate
Carmen Molins LeguaPilar Campíns FalcóAdela Sevillano Cabezasubject
Detection limitChromatographymedicine.diagnostic_testSodiumExtraction (chemistry)NQSchemistry.chemical_elementUrineBiochemistryAnalytical ChemistrychemistryStandard additionReagentSpectrophotometrymedicineEnvironmental ChemistrySpectroscopydescription
Abstract Sodium 1,2-naphthoquinone 4-sulphonate (NQS) was tested as a reagent for amphetamine in order to develop an extractive-spectrophotometric method for the drug in urine samples. The standard additions method showed the absence of proportional bias error whereas the Youden method and the two standard addition plots method showed the presence of a constant bias error [total Youden blank (TYB)]. Acceptable results were obtained by evaluating the TYB error or by using a placebo (urine sample from a normal subject). The dynamic range of concentrations was 1.4–50 mg 1−1 in urine samples and the detection limit was 0.6 mg 1−1 when 10 ml of urine sample were taken.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-11-01 | Analytica Chimica Acta |