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RESEARCH PRODUCT
Cell lineage and cell fate specification in the embryonic CNS of Drosophila.
Joachim UrbanGerhard M. Technausubject
education.field_of_studyNeuroectodermPopulationEctodermCell BiologyAnatomyBiologyCell fate determinationEmbryonic stem cellNeural stem cellCell biologymedicine.anatomical_structureNeuroblastmedicineProgenitor celleducationDevelopmental Biologydescription
The Drosophila CNS derives from a population of neural stem cells, called neuroblasts (NBs), which delaminate individually from the neurogenic region of the ectoderm. In the embryonic ventral nerve cord each NB can be uniquely identified and gives rise to a specific lineage consisting of neurons and/or glial cells. This 'NB identity' is dependent on the position of the progenitor cells in the neuroectoderm before delamination. The positional information is provided by the products of segment polarity and dorsoventral (D/V) patterning genes. Subsequently, 'cell fate genes' like huckebein (hkb) and eagle (eg) contribute to the generation of specific NB lineages. These genes act downstream of segment polarity and D/V patterning genes and regulate different processes such as the generation of glial cells and the determination of serotonergic neurons.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-08-01 | Seminars in celldevelopmental biology |