Antiplatelet Antibodies Do Not Predict the Response to Intravenous Immunoglobulins during Immune Thrombocytopenia

6533b828fe1ef96bd12885c8

RESEARCH PRODUCT

Antiplatelet Antibodies Do Not Predict the Response to Intravenous Immunoglobulins during Immune Thrombocytopenia

Arthur Imbach H. Greigert Christelle Mausservey Nadine Magy-bertrand Laurent Voillat Bernard Bonnotte Guillaume Mourey Sethi Ouandji Sylvain Audia Eric Deconinck Maxime Samson Thibault Ghesquière Denis Caillot Nicolas Falvo Jean-baptiste Picque Thomas Rogier

subject

IVIg Phagocytosis lcsh:Medicine 030204 cardiovascular system & hematology Article 03 medical and health sciences antiplatelet antibodies 0302 clinical medicine hemic and lymphatic diseases medicine Platelet Receptor 030304 developmental biology Autoimmune disease chemistry.chemical_classification 0303 health sciences biology business.industry lcsh:R Autoantibody General Medicine medicine.disease chemistry Mechanism of action immune thrombocytopenia Immunology biology.protein Antibody medicine.symptom Glycoprotein business circulatory and respiratory physiology

description

Immune thrombocytopenia (ITP) is a rare autoimmune disease due to autoantibodies targeting platelet glycoproteins (GP). The mechanism of platelet destruction could differ depending on the specificity of antiplatelet antibodies: anti-GPIIb/IIIa antibodies lead to phagocytosis by splenic macrophages, in a Fc&gamma

year	journal	country	edition	language
2020-06-25	Journal of Clinical Medicine

10.3390/jcm9061998 https://www.mdpi.com/2077-0383/9/6/1998

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