6533b828fe1ef96bd128863c

RESEARCH PRODUCT

Effect of plant sterol and galactooligosaccharides enriched beverages on oxidative stress and longevity in Caenorhabditis elegans

Salvador GenovésPatricia MartorellReyes BarberáAmparo AlegríaAntonio CillaGabriel López-garcía

subject

0301 basic medicinemedia_common.quotation_subjectMutantCholesterol oxidation productsMedicine (miscellaneous)Milk-based fruit beveragesmedicine.disease_causePlant sterols03 medical and health scienceschemistry.chemical_compound0404 agricultural biotechnologyIn vivomedicineTX341-641Caenorhabditis elegansTranscription factorCaenorhabditis elegansmedia_common030109 nutrition & dieteticsNutrition and DieteticsbiologyCholesterolNutrition. Foods and food supplyLongevity04 agricultural and veterinary sciencesbiology.organism_classification040401 food scienceNematodechemistryBiochemistryOxidative stressFood ScienceGalactooligosaccharides

description

Abstract This study evaluates the impact of two plant sterol (PS) enriched fruit beverages (0.6 g /100 ml), without (MfB) or with GOS (MfB-G) (1.2 g/100 ml) on the resistance against oxidative stress induced by non-conventional (cholesterol oxidation products (COPs)) and conventional (H2O2) oxidant compounds, as well as their impact on C. elegans longevity. Nematodes fed with both beverages (0.005–0.25%, v/v) showed similar improved oxidative stress resistance against COPs and H2O2. This effect was dependent on daf-16 transcription factor, although GOS showed an additional beneficial effect independent to daf-16. In addition, both beverages extended nematode lifespan, independently of the presence of GOS. Longevity assays using daf-16 and daf-2 mutant strains revealed that the observed effect was potentially linked to the insulin-IGF-1 pathway. These results provide new in vivo evidence for the potential use of PS enriched fruit beverages in the prevention of oxidative stress underlying many diseases.

yearjournalcountryeditionlanguage
2020-02-01Journal of Functional Foods
10.1016/j.jff.2019.103747http://www.sciencedirect.com/science/article/pii/S1756464619306711