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RESEARCH PRODUCT
1,2,3-Oligotriazoles modified halloysite nanotubes as potential active biological species: synthesis and characterization
Marina MassaroCarmelo Giuseppe CollettiGiuseppe CavallaroGiuseppe LazzaraPaolo Lo MeoSerena RielaRenato Notosubject
Halloysite nanotubes123-oligotriazolecovalent modificationOrganic ChemistryHuisgen reactionSettore CHIM/06 - Chimica OrganicaHNTs-prodrugSettore CHIM/02 - Chimica Fisicadescription
In the last years, the development of nano-formulations for cancer treatment represents one of the major challenges of the scientific research. The prodrug strategy, that combines chemotherapeutic agents with nanocarriers such as halloysite nanotubes (HNTs), is a promising strategy both to improve the biological activity of the drug molecules and to reduce the side effects of drugs. Herein we report the synthesis and characterization of a HNTs prodrug based on 1,2,3-triazole units covalently linked to HNTs external surface, bearing different positively charged moieties, which could present interesting pharmacological activities.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-01-27 | Arkivoc |