6533b828fe1ef96bd1288c6f

RESEARCH PRODUCT

Synthetic Application of Homogeneous Charge Transfer Catalysis in the Electrocarboxylation of Benzyl Halides

Giuseppe SilvestriGiuseppe FilardoAlessandro GaliaOnofrio ScialdoneDavide Mantione

subject

chemistry.chemical_compoundchemistryCarboxylationInorganic chemistryOuter sphere electron transferHalideCharge (physics)Homogeneous catalysisMethyl benzoateDecompositionCatalysis

description

The results of an investigation on the performances of some outer sphere electron transfer homogeneous catalysts in the electrocarboxylation of 1-(p-isobutyl-phenyl)-1-chloroethane to 2-(p-isobutyl-phenyl)-propionic acid (Ibuprofen), using as catalysts the esters of benzoic and o-, m-, and p-phtalic acids, are reported. The performances of the catalysts are evaluated on the basis of the following parameters: faradic yields of the carboxylation and decomposition of the catalyst. The performances of dimethylisophtalate have been examined in greater detail. The rate of decomposition of the catalyst is related to the molar ratio [halide]/[catalyst].

yearjournalcountryeditionlanguage
1998-01-01
https://doi.org/10.1007/978-4-431-65924-2_71