6533b828fe1ef96bd1288c7b

RESEARCH PRODUCT

Alteration of Esophageal Peristalsis by Pentagastrin in Patients with Diffuse Esophageal Spasm

K. EweKrüger JEckhardt VfHoltermüller Kh

subject

medicine.medical_specialtyContraction (grammar)business.industrydigestive oral and skin physiologyGastroenterologyGastroenterologyDenervation supersensitivityPentagastrinIn vivoInternal medicinemedicineIn patientEsophageal spasmEsophageal peristalsisbusinessGastrinmedicine.drug

description

Although it has been shown that gastrin and gastric alkalinization affect the lower esophageal sphincter, in vivo studies have not demonstrated a measurable effect of pentagastrin on esophageal peristalsis. In 9 patients with diffuse esophageal spam and in 10 control subjects esophageal peristalsis was recorded before and after pentagastrin infections. Subcutaneous pentagastrin increased peak amplitude significantly more in patients, 31.2 +/- 8.1 mm Hg (mean +/- S.E.M.), than in controls, 12.1 +/- 5.1 mm Hg (P less than 0.02). Max. duration of contraction waves in patients showed a rise of 11.3 +/- 2.7 sec as compared to controls, 1.9 +/- 0.9 sec (P less than 0.01). The effect of pentagastrin on esophageal peristalsis in patients with diffuse esophageal spasm may be explained as denervation supersensitivity.

yearjournalcountryeditionlanguage
1975-08-01Scandinavian Journal of Gastroenterology
https://doi.org/10.1080/00365521.1975.12096998