6533b828fe1ef96bd1288e75

RESEARCH PRODUCT

Antiviral Agents From Fungi : Diversity, Mechanisms and Potential Applications

Varpu MarjomäkiDhanik ReshamwalaMarta Cortina-escribanoPyry VeteliRiikka LinnakoskiHenri Vanhanen

subject

0301 basic medicineMicrobiology (medical)endofyytitnatural productsBioactive moleculesmedia_common.quotation_subjectantiviral mechanismslcsh:QR1-502fungal secondary metabolitesendophytesluonnontuotteetReviewComputational biologyBiology01 natural sciencesMicrobiologylcsh:Microbiology03 medical and health sciencesantiviral agentsSpecies identificationpuolustusmekanismit (biologia)media_commonantimikrobiset yhdisteet010405 organic chemistrymedicinal mushroomsta1183ta1182luonnonaineet0104 chemical sciences030104 developmental biologyvirustauditsienetDiversity (politics)

description

Viral infections are amongst the most common diseases affecting people worldwide. New viruses emerge all the time and presently we have limited number of vaccines and only few antivirals to combat viral diseases. Fungi represent a vast source of bioactive molecules, which could potentially be used as antivirals in the future. Here, we have summarized the current knowledge of fungi as producers of antiviral compounds and discuss their potential applications. In particular, we have investigated how the antiviral action has been assessed and what is known about the molecular mechanisms and actual targets. Furthermore, we highlight the importance of accurate fungal species identification on antiviral and other natural products studies. peerReviewed

http://urn.fi/URN:NBN:fi:jyu-201810024298