6533b828fe1ef96bd1288eaf
RESEARCH PRODUCT
Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype
Giorgio StassiSimone Di Francosubject
cancer stem cellCancer ResearchStromal cellTransition (genetics)Colorectal cancerbusiness.industryadipose stromal cellMesenchymal stem cellAdipose tissuecolorectal cancermedicine.diseasePhenotypedigestive system diseaseshybrid EMTCommentaryMolecular mechanismCancer researchmedicineMolecular MedicineSettore MED/46 - Scienze Tecniche Di Medicina Di LaboratorioStem cellbusinessobesity.Article Commentarydescription
ABSTRACT Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal traits. Targeting of adipose-derived factors abrogate the metastatic potential of CRC stem cells (CR-CSCs) in obese patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-10-01 | Molecular & Cellular Oncology |