6533b828fe1ef96bd128905b
RESEARCH PRODUCT
Keeping memory clear and stable--the contribution of human basal ganglia and prefrontal cortex to working memory.
Marianne DieterichCarolin HeinzeFrank BirkleinHans-otto KarnathNotger G. MüllerBernhard Baiersubject
AdultMalephysiology [Prefrontal Cortex]Interference theoryphysiology [Basal Ganglia]Prefrontal CortexBrain mappingBasal GangliaBasal (phylogenetics)Cortex (anatomy)Basal gangliamedicineHumansphysiopathology [Memory Disorders]complications [Stroke]ddc:610Prefrontal cortexAgedAged 80 and overMemory DisordersBrain Mappingphysiopathology [Stroke]Working memoryGeneral NeurosciencePutamenphysiology [Putamen]Middle AgedMagnetic Resonance Imagingetiology [Memory Disorders]StrokeMemory Short-Termmedicine.anatomical_structurephysiology [Memory Short-Term]pathology [Stroke]Femalediagnosis [Memory Disorders]physiopathology [Putamen]Brief CommunicationsConsumer neurosciencePsychologyNeuroscienceCognitive psychologydescription
Successful remembering involves both hindering irrelevant information from entering working memory (WM) and actively maintaining relevant information online. Using a voxelwise lesion-behavior brain mapping approach in stroke patients, we observed that lesions of the left basal ganglia render WM susceptible to irrelevant information. Lesions of the right prefrontal cortex on the other hand make it difficult to keep more than a few items in WM. These findings support basal ganglia-prefrontal cortex models of WM whereby the basal ganglia play a gatekeeper role and allow only relevant information to enter prefrontal cortex where this information then is actively maintained in WM.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-07-21 |