6533b828fe1ef96bd1289132

RESEARCH PRODUCT

On the geographical distribution of pseudocholinesterase variants.

Hildegard Steegmüller

subject

AsiaNative Hawaiian or Other Pacific IslanderGenotypePopulationDistribution (economics)IndiaBiologyGene FrequencyGenetic modelStatisticsGenetic variationCholinesterasesHumansAlleleeducationBulgariaAllele frequencyMolecular BiologyAlleleseducation.field_of_studybusiness.industryIncidence (epidemiology)Racial GroupsGermany WestGenetic VariationGeneral MedicineEuropeGenetics PopulationButyrylcholinesteraseAfricaAmericasbusiness

description

The incidence of pseudocholinesterase (PCHE equals E.C. 3.1.1.8) variants in samples of 8 different population (total of 2218 individuals) is reported. Together with previously mentioned data from the literature, a general survey on the geographical distribution of PCHE isoenzymes is given. Possible reasons for present-day heterogeneity of their distribution are also discussed. Concerning the incidence of the C5 variant, it is pointed out that the validity of applying population genetic models depends upon the accuracy of the genetic basis.

yearjournalcountryeditionlanguage
1975-09-01Humangenetik
10.1007/bf00281451https://pubmed.ncbi.nlm.nih.gov/48494