6533b828fe1ef96bd1289133
RESEARCH PRODUCT
The ageing and myasthenic thymus: a morphometric study validating a standard procedure in the histological workup of thymic specimens.
Reinhard KieferNick WillcoxMaria Isabel LeiteRegina MoritzRalf GoldWilfred NixHans Konrad Müller-hermelinkPhilipp StröbelAlexander MarxBerthold SchalkeWen-yu ChuangAlfred JaretzkiJohn Newsom-davissubject
AdultMaleAgingPathologymedicine.medical_specialtyThymomaAdolescentThymomamedicine.medical_treatmentImmunologyThymus GlandThymus Extractslaw.inventionSex FactorsAtrophyRandomized controlled triallawMyasthenia GravismedicineHumansImmunology and AllergyChildRandomized Controlled Trials as TopicThymus extractThymus Neoplasmbusiness.industryAge FactorsAutoantibodyReproducibility of ResultsThymus NeoplasmsThymectomymedicine.diseaseImmunohistochemistryMyasthenia gravisThymectomyNeurologyFemaleNeurology (clinical)businessdescription
The thymus is believed to play an important role in the pathogenesis of myasthenia gravis (MG). The 80% of MG patients with anti-acetylcholine receptor autoantibodies fall into three clinical subgroups: 1) thymoma; 2) early-onset MG (<age of 40; EOMG) and 3) late-onset (LOMG; onset after 40). Thymectomy is widely used in EOMG, but its benefits have not been established in randomized controlled trials. A multicenter international trial (MGTX) currently seeks to determine whether thymectomy reduces corticosteroid requirements, and to look for correlations with thymic histology. We here describe the validated, standardized histological workup and reporting system used in this trial.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-09-01 | Journal of neuroimmunology |