6533b829fe1ef96bd1289703

RESEARCH PRODUCT

In vivo measurement of gastric fluid volume in anesthetized dogs

Zhen LiuHarvey HoKang LiZhihui HaoZhihui HaoBing ZhaiPeter LangguthChunmei WangChunmei WangHuayong GuCuncai WangHui GuoPingping Wang

subject

Gastric fluidmedicine.diagnostic_testbusiness.industryPharmaceutical ScienceMagnetic resonance imaging02 engineering and technology021001 nanoscience & nanotechnologyWeight rangeBiopharmaceutics Classification System030226 pharmacology & pharmacyBeagle03 medical and health sciences0302 clinical medicineVolume (thermodynamics)In vivoMedicineSolubility0210 nano-technologybusinessBiomedical engineering

description

Abstract The drug solubility is critical for the Biopharmaceutics Classification System (BCS), yet the criteria for solubility have not been precisely defined for dogs. In particular, the gastric fluid volume (GFV) of dogs which is used to measure the solubility has not been quantified in vivo. The aim of the work is to measure the GFV using magnetic resonance imaging (MRI) from 12 Beagle dogs weighing 9–12 kg (6 male and 6 female). We found that the average GFV within this weight range was 24.0 ± 4.2 mL. The result can be used for the BCS studies of canine drugs and also serves as a reference for other species.

yearjournalcountryeditionlanguage
2020-02-01Journal of Drug Delivery Science and Technology
https://doi.org/10.1016/j.jddst.2019.101488