6533b829fe1ef96bd1289737

RESEARCH PRODUCT

Choline Fluxes to and from the Rat Cerebral Cortex Studied with the “Cup Technique” in Vivo

Giancarlo PepeuKonrad LöffelholzR. BrehmRenato Corradetti

subject

Endogenychemistry.chemical_compoundmedicine.anatomical_structurechemistryCerebral cortexIn vivoExtracellularBiophysicsmedicineCholinesense organsEffluxNeuroscienceAcetylcholinemedicine.drug

description

Since MacIntosh and Oborin (11) and later Mitchell (12) introduced the “cup technique” as a mean to study acetylcholine release from the cerebral cortex in vivo, this technique has been widely used for investigating the release of various neurotransmitters in anaesthetized as well as unanaesthetized mammals (2, 13, 14). Recently we proposed the “cup technique” as a way for studying the efflux of endogenous choline (Ch) from the rat cerebral cortex (4, 5) and to estimate changes in the extracellular concentration of Ch, if we consider the fluid filling the cup as an extension of the extracellular space.

yearjournalcountryeditionlanguage
1986-01-01
https://doi.org/10.1007/978-1-4684-5194-8_79