6533b829fe1ef96bd12897d8
RESEARCH PRODUCT
Flavans and other chemical constituents of Crinum biflorum (Amaryllidaceae)
Boris Y. KianféTill OpatzRoland T. TchuenguemSoleiman E. HelalyJean Paul DzoyemBeaudelaire Kemvoufo PonouRémy Bertrand TeponnoLéon Azefack TapondjouJonas Kühlbornsubject
Chromatographybiology010405 organic chemistryEthyl acetateAbsolute configurationPancratistatinbiology.organism_classification01 natural sciencesBiochemistry0104 chemical sciences010404 medicinal & biomolecular chemistrychemistry.chemical_compoundchemistryPhytochemicalCrinumKaempferolOleanolic acidEcology Evolution Behavior and SystematicsLupeoldescription
Abstract The ethyl acetate extract from the whole plant of Crinum biflorum Rottb. Showed a moderate activity against Enterococcus faecalis. Its phytochemical investigation led to the isolation of a new flavan-3-ol derivative namely (2R,3R)-3-hydroxy-7-methoxy-3′,4′-methylenedioxyflavan, together with (2S)-7-hydroxy-3′,4′-methylenedioxyflavan, (2R,3R)-7-methoxy-flavan-3-ol, (2S)-7-hydroxy-3′,4′-dimethoxyflavan, 3′,7-dihydroxy-4′-methoxyflavan, 4′,7-dimethoxy-3′-hydroxyflavan, farrerol, β-sitosterol, β-sitosterol-3-O-β-D-glucopyranoside, oleanolic acid, kaempferol, pancratistatin, lupeol, aurantiamide acetate, Narciprimine and 2,3-dihydroxypropyl palmitate. Their structures were elucidated mainly by extensive spectroscopic analysis and comparison with published data. The absolute configuration of the new metabolite was determined by electronic circular dichroism (ECD) analysis and comparison of optical rotation. Some of the isolated compounds were tested for their antimicrobial activity but no inhibition was observed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-12-01 | Biochemical Systematics and Ecology |