A nitroreductase and glutathione responsive nanoplatform for integration of gene delivery and near-infrared fluorescence imaging

6533b829fe1ef96bd12898b7

RESEARCH PRODUCT

A nitroreductase and glutathione responsive nanoplatform for integration of gene delivery and near-infrared fluorescence imaging

Hong Liang Yu Nie Xiaobing Chen Qunjie Bi Bowen Ke Rongrong Jin Xu Song Matthias Barz Ao Hu

subject

Indocyanine Green Glutathione metabolism Fluorescence-lifetime imaging microscopy Near-Infrared Fluorescence Imaging Infrared Rays Peptide Gene delivery Catalysis chemistry.chemical_compound Nitroreductase Optical imaging Materials Chemistry Humans Fluorescent Dyes chemistry.chemical_classification Optical Imaging Gene Transfer Techniques Metals and Alloys food and beverages General Chemistry Glutathione Nitroreductases Glutathione Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry Ceramics and Composites Biophysics Peptides HeLa Cells

description

A novel platform rationally integrating indocyanine green analogues and an arginine-rich dendritic peptide with both nitroreductase (NTR) and glutathione (GSH) reduction responsive linkers was developed. This multifunctional platform can enable selective and efficient gene delivery and specific turn-on fluorescence imaging in tumors.

year	journal	country	edition	language
2020-05-18	Chemical Communications

https://doi.org/10.1039/c9cc10071g

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