0000000000644003

AUTHOR

Bowen Ke

showing 2 related works from this author

A nitroreductase and glutathione responsive nanoplatform for integration of gene delivery and near-infrared fluorescence imaging

2020

A novel platform rationally integrating indocyanine green analogues and an arginine-rich dendritic peptide with both nitroreductase (NTR) and glutathione (GSH) reduction responsive linkers was developed. This multifunctional platform can enable selective and efficient gene delivery and specific turn-on fluorescence imaging in tumors.

Indocyanine GreenGlutathione metabolismFluorescence-lifetime imaging microscopyNear-Infrared Fluorescence ImagingInfrared RaysPeptideGene deliveryCatalysischemistry.chemical_compoundNitroreductaseOptical imagingMaterials ChemistryHumansFluorescent Dyeschemistry.chemical_classificationOptical ImagingGene Transfer TechniquesMetals and Alloysfood and beveragesGeneral ChemistryGlutathioneNitroreductasesGlutathioneSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialschemistryCeramics and CompositesBiophysicsPeptidesHeLa CellsChemical Communications
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Integration of Indocyanine Green Analogs as Near‐Infrared Fluorescent Carrier for Precise Imaging‐Guided Gene Delivery

2020

Codelivery of diagnostic probes and therapeutic molecules often suffers from intrinsic complexity and premature leakage from or degradation of the nanocarrier. Inspired by the "Y" shape of indocyanine green (ICG), the dye is integrated in an amphiphilic lipopeptide (RNF). The hydrophilic segment is composed of arginine-rich dendritic peptides, while cyanine dyes are modified with two long carbon chains and employed as the hydrophobic moiety. They are linked through a disulfide linkage to improve the responsivity in the tumor microenvironment. After formulation with other lipopeptides at an optimized ratio, the theranostic system (RNS-2) forms lipid-based nanoparticles with slight positive z…

Indocyanine Green02 engineering and technologyGene delivery010402 general chemistry01 natural sciencesBiomaterialsMicechemistry.chemical_compoundAmphiphileAnimalsGeneral Materials ScienceCyanineFluorescent DyesChemistryOptical ImagingGene Transfer TechniquesGeneral Chemistry021001 nanoscience & nanotechnologyFluorescence0104 chemical sciencesFörster resonance energy transferLipofectamineBiophysicsNanoparticlesNanocarriers0210 nano-technologyIndocyanine greenBiotechnologySmall
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