Elucidation of the biosynthesis and degradation of allantofuranone by isotopic labelling and fermentation of modified precursors.

6533b829fe1ef96bd1289928

RESEARCH PRODUCT

Elucidation of the biosynthesis and degradation of allantofuranone by isotopic labelling and fermentation of modified precursors.

Johannes C. Liermann Anja Schüffler Timm Anke Till Opatz

subject

Abiotic component Antifungal Agents Organic Chemistry Fungi Polyporic acid Phenylalanine Biology Biochemistry Isotopic labeling chemistry.chemical_compound Biosynthesis chemistry Biochemistry 4-Butyrolactone Labelling Isotope Labeling Fermentation Molecular Medicine Degradation (geology)Fermentation Molecular Biology

description

Feeding experiments with the ascomycete Allantophomopsis lycopodina indicated that the potent fungistatic allantofuranone is biosynthesized from phenylalanine. Further experiments with synthetic precursors gave evidence that the naturally occurring polyporic acid serves as a key intermediate in the biosynthesis. In addition to the formation of allantofuranone, its abiotic and metabolic degradation were investigated.

year	journal	country	edition	language
2010-12-22	Chembiochem : a European journal of chemical biology

10.1002/cbic.201000448 https://pubmed.ncbi.nlm.nih.gov/21181846

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