6533b829fe1ef96bd128993a
RESEARCH PRODUCT
A preliminary study on the stability of benzodiazepines in blood and plasma stored at 4 degrees C.
Rainer MatternI KönigLucia PötschGisela Skoppsubject
AnalyteChromatographyChromatography GasPlasma samplesChemistryObservation periodForensic toxicologyPlasmaForensic MedicinePathology and Forensic MedicineSpecimen HandlingSubstance Abuse DetectionBenzodiazepinesPlasmaBloodReference ValuesRefrigerationReference valuesLinear ModelsHumansGas chromatographydescription
An approach to determine the stability of benzodiazepines and some of their metabolites (n = 13) by means of a routinely applied gas chromatographic method using electron capture detection was made in this preliminary study. Validation data of the method are given. Spiked blood and plasma samples were stored at 4 degrees C and analysed at selected times up to 240 days. The concentrations of all analytes had decreased to at least 60% of the original levels at the end of the observation period. A clear pattern of breakdown could not be established. The data obtained suggest that results from long-term stored samples should be interpreted cautiously. Further investigations concerning the stability of drugs in blood and plasma samples, additional methods of identification and determination as well as the establishment of optimal storage conditions seem necessary.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-12-19 | International journal of legal medicine |