Interfacial Self-Assembly to Spatially Organize Graphene Oxide Into Hierarchical and Bioactive Structures

6533b829fe1ef96bd1289b92

RESEARCH PRODUCT

Interfacial Self-Assembly to Spatially Organize Graphene Oxide Into Hierarchical and Bioactive Structures

Anna Majkowska Anna Majkowska Anna Majkowska Carlos Redondo-gómez Carlos Redondo-gómez Alistair Rice Mariel Gonzalez Karla E. Inostroza-brito Estelle C. Collin Jose Carlos Rodriguez-cabello Armando E. Del Rio Hernandez Egle Solito Alvaro Mata Alvaro Mata Alvaro Mata Alvaro Mata Alvaro Mata

subject

Technology Materials science Biocompatibility Scanning electron microscope Materials Science (miscellaneous)Materials Science composite materials FABRICATION Materials Science Multidisciplinary hierarchical biomaterials Nanotechnology 02 engineering and technology 010402 general chemistry lcsh:Technology 01 natural sciences elastin-like recombinamer law.invention DESIGN law Peptide amphiphile BIOMATERIALS 0912 Materials Engineering CHITOSAN Science & Technology 1007 Nanotechnology lcsh:T Graphene SCAFFOLD 021001 nanoscience & nanotechnology Microstructure peptide amphiphiles 0104 chemical sciences multicomponent self-assembly DIFFERENTIATION Membrane Transmission electron microscopy graphene oxide Self-assembly 0210 nano-technology FILM

description

Multicomponent self-assembly holds great promise for the generation of complex and functional biomaterials with hierarchical microstructure. Here, we describe the use of supramolecular co-assembly between an elastin-like recombinamer (ELR5) and a peptide amphiphile (PA) to organize graphene oxide (GO) flakes into bioactive structures across multiple scales. The process takes advantage of a reaction—diffusion mechanism to enable the incorporation and spatial organization of GO within multiple ELR5/PA layers. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and ImageJ software were used to demonstrate the hierarchical organization of GO flakes within the ELR5/PA layers and the distribution profiles of GO throughout the ELR5/PA membranes. Furthermore, atomic force microscopy (AFM) revealed improved Young's Moduli of the ELR5/PA/GO membranes compared to the ELR5/PA membranes. Lastly, we investigated biocompatibility of the ELR5/PA/GO membrane via various cell culture methods.

year	journal	country	edition	language
2020-06-16	Frontiers in Materials

https://doi.org/10.3389/fmats.2020.00167