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RESEARCH PRODUCT

A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Henrik HjalgrimBruce K. ArmstrongMarina CorinesBengt GlimeliusBengt GlimeliusXifeng WuGraham G. GilesGraham G. GilesChristine F. SkibolaKimberly A. BertrandCarrie A. ThompsonBrenda M. BirmannWendy CozenAnne J. NovakEleanor KaneClaire M. VajdicW. Ryan DiverJoseph F. FraumeniThomas E. WitzigMads MelbyeMads MelbyeZhaoming WangAnn MariaLucia CondeRebecca MontalvanGianluca SeveriGianluca SeveriJoseph VijaiMeredith YeagerJames MckaySusan L. SlagerAngela Brooks-wilsonAngela Brooks-wilsonKenneth OffitAlain MonnereauKari E. NorthJacques RibyTheodore R. HolfordSilvia De SanjoséLucia MiligiTinu ThomasDemetrius AlbanesRoel VermeulenLesley F. TinkerLauren R. TerasJohn J. SpinelliTongzhang ZhengJarmo VirtamoBaoshan MaBaoshan MaEve RomanCharles E. LawrenceNikolaus BeckerTracy LightfootLenka ForetovaAnne KrickerRichard K. SeversonJames R. CerhanCharles C. ChungMaria Grazia EnnasRachel S. KellyRosalia RiccoBrian K. LinkAlexandra NietersSophia S. WangPaul BrennanPeter KraftHans-olov AdamiHans-olov AdamiYawei ZhangLaurie BurdettJinyan HuangMartyn T. SmithYuanqing YeJenny TurnerPatricia HartgeAnne Zeleniuch-jacquotteQing LanGiovanni Maria FerriSonja I. BerndtBrian C.-h. ChiuElizabeth A. HollyStephen J. ChanockStephen M. AnsellJian GuLiming LiangPaolo VineisCarol S. PortlockDanylo J. VillanoMarc MaynadiePaige M. BracciNathaniel RothmanYolanda BenaventePaul I.w. De BakkerAlex SmithAnthony StainesRebecca D. JacksonLindsay M. MortonMark LiebowKarin E. SmedbyGeorge J. WeinerAmy HutchinsonThomas M. HabermannJacqueline ClavelAnneclaire J. De RoosAnneclaire J. De RoosEdward GiovannucciMark P. PurdueAhmet DoganPaolo Boffetta

subject

Medicin och hälsovetenskapLymphomaResearch Support U.S. Gov't P.H.S.Follicular lymphomaGeneral Physics and AstronomyGenome-wide association studyMarginal ZoneP.H.S.Medical and Health SciencesMajor Histocompatibility ComplexPolymorphism (computer science)Non-U.S. Gov'tGENE-EXPRESSIONCELL DEVELOPMENTGeneticsMultidisciplinaryMembrane GlycoproteinsResearch Support Non-U.S. Gov'tSingle NucleotideMarginal zone3. Good healthMultidisciplinary SciencesScience & Technology - Other TopicsNON-HODGKIN-LYMPHOMASUSCEPTIBILITY LOCIGenotypeCèl·lules BEuropean Continental Ancestry GroupEPIDEMIOLOGIC RESEARCHHuman leukocyte antigenBiologyResearch SupportPolymorphism Single NucleotideCLASSIFICATIONGeneral Biochemistry Genetics and Molecular BiologyWhite PeopleArticleN.I.H.Research Support N.I.H. ExtramuralMarginal zone lymphomaMD MultidisciplinaryGenetic variationmedicineJournal ArticleHumansPolymorphismGASTRIC LYMPHOMAIntramuralB cellsScience & TechnologyButyrophilinsGastric lymphomaB-CellExtramuralComputational BiologyGeneral ChemistryLymphoma B-Cell Marginal ZoneResearch Support N.I.H. Intramuralmedicine.diseaseRISK LOCIRHEUMATOID-ARTHRITISLymphomaMalaltia de HodgkinImmunologyU.S. Gov'tHodgkin's diseaseFOLLICULAR LYMPHOMAGenome-Wide Association Study

description

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10−15) and HLA-B (rs2922994, P=2.43 × 10−9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

yearjournalcountryeditionlanguage
2015-01-08
10.1038/ncomms6751http://hdl.handle.net/2445/126171