Stereocontrolled approach to δ- and γ-lactones and 1,3-diols. The role of X− ion in the selenolactonization

6533b829fe1ef96bd128a3d8

RESEARCH PRODUCT

Stereocontrolled approach to δ- and γ-lactones and 1,3-diols. The role of X− ion in the selenolactonization

Michelangelo Gruttadauria Carmela Aprile Renato Noto

subject

Selenium Cyclization Stereochemistry Chemistry Organic Chemistry Drug Discovery chemistry.chemical_element Stereoselectivity Biochemistry Selenium Ion

description

Abstract Two complementary approaches have been realized for the stereoselective synthesis of 4,6-disubstituted δ-lactones and 1,3- anti and syn diols. In the 6- endo selenolactonization the role of the X − ion on the stereoselectivity is shown. Moreover, the highly stereoselective transformation of the 6- endo δ-lactone to the 5- exo γ-lactone is reported.

year	journal	country	edition	language
2002-02-25	Tetrahedron Letters

https://doi.org/10.1016/s0040-4039(02)00093-x

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