6533b829fe1ef96bd128a4e3
RESEARCH PRODUCT
Genetic basis of dental agenesis - molecular genetics patterning clinical dentistry
Nidhi ChhabraAnuj ChhabraMridula Goswamisubject
medicine.medical_specialtyDentistryOdontologíaReviewBiologyAnodontiaMolecular geneticsAXIN2medicineTooth lossHumansMolecular BiologyGeneral DentistryAnodontiaGeneticsOral Medicine and Pathologybusiness.industryFibroblast growth factor receptor 1Wnt signaling pathwaySyndrome:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseCiencias de la saludstomatognathic diseasesHypodontiaOtorhinolaryngologyDentistryUNESCO::CIENCIAS MÉDICASOdontogenesisSurgerymedicine.symptombusinessPAX9description
Tooth agenesis is one of the most common congenital malformations in humans. Hypodontia can either occur as an isolated condition (non-syndromic hypodontia) or can be associated with a syndrome (syndromic hypodontia), highlighting the heterogeneity of the condition. Though much progress has been made to identify the developmental basis of tooth formation, knowledge of the etiological basis of inherited tooth loss is still lacking. To date, the mutation spectra of non-syndromic form of familial and sporadic tooth agenesis in humans have revealed defects in various such genes that encode transcription factors, MSX1 and PAX9 or genes that code for a protein involved in canonical Wnt signaling (AXIN2), and a transmembrane receptor of fibroblast growth factors (FGFR1). The aim of this paper is to review the current literature on the molecular mechanisms responsible for selective hypodontia in humans and to present a detailed overview of causative genes and syndromes associated with hypodontia. Key words:Tooth agenesis, hypodontia, growth factors, mutations.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-03-04 | Medicina Oral Patología Oral y Cirugia Bucal |