6533b829fe1ef96bd128a4f6
RESEARCH PRODUCT
Lymphatic absorption of phytosterol oxides in rats
Christian GihièsAndré GrandgirardJean-pierre SergielMohammed NourJoelle Demaison-melochesubject
MaleAdult male030309 nutrition & dieteticsCampesterolAbsorption (skin)BiochemistryMass SpectrometryLymphatic System03 medical and health scienceschemistry.chemical_compoundpolycyclic compoundsAnimalsOrganic chemistryRats Wistar[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM][SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM]ComputingMilieux_MISCELLANEOUS030304 developmental biology0303 health sciencesChromatographyPhytosterolOrganic ChemistryPhytosterolsCell BiologyRatsLymphatic systemchemistryRATlipids (amino acids peptides and proteins)Lymphdescription
Two of the main classes of oxyphytosterols (7-keto and epoxides) were synthesized from sitosterol and campesterol and given to mesenteric duct-cannulated adult male rats. Lymph was collected during 24 h and was analyzed for oxysterols. The results showed that the lymphatic recovery of the phytosterol oxides was low: 4.7% of the given dose for epoxy derivatives and 1.5% for 7-keto compounds. The campesterol oxides presented a better absorption than the sitosterol oxides. During the process of absorption, the epoxyphytostanols were also partly transformed in campestanetriol and stigmastanetriol.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-01-01 |